Enhancing efficacy of gemcitabine in pancreatic patient-derived xenograft mouse models
نویسندگان
چکیده
منابع مشابه
MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)
A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model. Seven weeks after implantation, PDOX nude mice were divided into the following groups: untreated control (n = 7); gemcitabine (100 mg/kg, i.p., once a week for 2 weeks, n = 7); cobimetinib (5 mg/kg, p.o., 14 cons...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics: X
سال: 2020
ISSN: 2590-1567
DOI: 10.1016/j.ijpx.2020.100056